Been a long time user of ArkiveUI in WoW and tried to re-create the idea.
Basically a symmetrical, centered layout that is oriented at the bottom of the screen. unit frames are all close together for minimized mouse-movement when targeting.
Have not yet had a chance to test the setup in group, but ideally should be able to fulfill all roles, particularly healing.
All panels are active except for the menu bar, which I disabled since I am using the shortcuts. I am using maximum video settings on a 1920 x 1080 resolution. Screen real estate is 23" so I could afford to scale down the UI to 0.65, which allows for better visibility of the surroundings.