The idea here with this UI is to put everything essential in your field of view.

Hotbars 6 and 5 have are enlarged and have only 3 slots each. I use these for cooldowns and have placed them above and beside my main block of abilities.

I use a Razer Naga and Orbweaver, that is why the hotbars are sized 3x4 and 4x3.

The map is at top center and faded a little. It was very different at first but I have found it somewhat easier to glance at now that I am looking in its direction anyway.