I am a Merc Healer using a Razer Naga mouse. The layout has the Operations Frames in between my mouse keypad layout for unmodified and alt-modified keys. The remaining two bars have items unbound to keys (click) and my emergency/frequent use key (Mount (Q), Buff (E), MedPack (Alt-Q), Determination (Alt-E).

I am thinking about rearranging the last two bars so that they reflect 6x2x2 for QWERTY/ASDFGH/ZXCVBN keys and move them to the lower left when my companion information is now.